Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BACKGROUND: In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at metamorphosis; the larger number and higher levels...

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Библиографические подробности
Опубликовано в: :BMC Biol
Главные авторы: Khan, Anzer, Paro, Simona, McGurk, Leeanne, Sambrani, Nagraj, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020516/
https://ncbi.nlm.nih.gov/pubmed/32059717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-0747-0
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