Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BACKGROUND: In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at metamorphosis; the larger number and higher levels...

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Udgivet i:BMC Biol
Main Authors: Khan, Anzer, Paro, Simona, McGurk, Leeanne, Sambrani, Nagraj, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020516/
https://ncbi.nlm.nih.gov/pubmed/32059717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-0747-0
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