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Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes
Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27 knockout mice were born at expected Mendelian...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7101378/ https://ncbi.nlm.nih.gov/pubmed/32221326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62358-4 |
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