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An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production

The prevalence of type 2 diabetes in the United States is projected to double or triple by 2050. We reasoned that the genes that modulate insulin production might be new targets for diabetes therapeutics. Therefore, we developed an siRNA screening system to identify genes important for the activity...

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Bibliografske podrobnosti
Main Authors: Ku, Gregory M., Pappalardo, Zachary, Luo, Chun Chieh, German, Michael S., McManus, Michael T.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257298/
https://ncbi.nlm.nih.gov/pubmed/22253604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002449
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