Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

OBJECTIVE: The G-protein–coupled receptor GPR40 mediates fatty acid potentiation of glucose-stimulated insulin secretion, but its contribution to insulin secretion in vivo and mechanisms of action remain uncertain. This study was aimed to ascertain whether GPR40 controls insulin secretion in vivo an...

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Detalhes bibliográficos
Main Authors: Alquier, Thierry, Peyot, Marie-Line, Latour, Martin G., Kebede, Melkam, Sorensen, Christina M., Gesta, Stephane, Ronald Kahn, C., Smith, Richard D., Jetton, Thomas L., Metz, Thomas O., Prentki, Marc, Poitout, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768167/
https://ncbi.nlm.nih.gov/pubmed/19720802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0362
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