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Mortalin (HSPA9) facilitates BRAF–mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability
Mortalin [also known as heat shock protein family A (Hsp70) member 9 (HSPA9) or glucose-regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often upregulated and mislocalized in tumors with abnormal activation of the kinases MEK and ERK. Here, we found that mortalin depletio...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7099430/ https://ncbi.nlm.nih.gov/pubmed/32156782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay1478 |
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