Mortalin (HSPA9) facilitates BRAF–mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability

Mortalin [also known as heat shock protein family A (Hsp70) member 9 (HSPA9) or glucose-regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often upregulated and mislocalized in tumors with abnormal activation of the kinases MEK and ERK. Here, we found that mortalin depletio...

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Pubblicato in:Sci Signal
Autori principali: Wu, Pui-Kei, Hong, Seung-Keun, Chen, Wenjing, Becker, Andrew E., Gundry, Rebekah L., Lin, Chien-Wei, Shao, Hao, Gestwicki, Jason E., Park, Jong-In
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099430/
https://ncbi.nlm.nih.gov/pubmed/32156782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay1478
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