Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can selectively induce death of immortalized normal fibroblasts IMR90E1A when combined with K-Ras(G12V) expression, but not with wild ty...

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Vydáno v:Oncogene
Hlavní autoři: Wu, Pui-Kei, Hong, Seung-Keun, Starenki, Dmytro, Oshima, Kiyoko, Shao, Hao, Gestwicki, Jason E., Tsai, Susan, Park, Jong-In
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244387/
https://ncbi.nlm.nih.gov/pubmed/32291414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1285-5
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