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Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy
Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) are essential for normal energy homeostasis. Maximal ARC Pomc transcription is dependent on neuronal Pomc enhancer 1 (nPE1), located 12kb upstream from the promoter. Selective deletion of nPE1 in mice decreases ARC Pomc exp...
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| Pubblicato in: | J Endocrinol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098466/ https://ncbi.nlm.nih.gov/pubmed/32027603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-19-0576 |
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