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The Sts1 nuclear import adapter uses a non-canonical bipartite nuclear localization signal and is directly degraded by the proteasome

The proteasome is an essential regulator of protein homeostasis. In yeast and many mammalian cells, proteasomes strongly concentrate in the nucleus. Sts1 from the yeast Saccharomyces cerevisiae is an essential protein linked to proteasome nuclear localization. Here, we show that Sts1 contains a non-...

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Publicado en:J Cell Sci
Autores principales: Budenholzer, Lauren, Breckel, Carolyn, Hickey, Christopher M., Hochstrasser, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7097302/
https://ncbi.nlm.nih.gov/pubmed/32041904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.236158
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