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A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs
The cryptophycins are a family of macrocyclic depsipeptide natural products that display exceptionally potent anti-proliferative activity against drug-resistant cancers. Unique challenges facing the synthesis and derivatization of this complex group of molecules motivated us to investigate a chemoen...
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| izdano v: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7094870/ https://ncbi.nlm.nih.gov/pubmed/31961651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00998 |
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