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Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond Forming NRPS Module

Cryptophycins are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new generation of analogs with improved medicinal properties. Herein, we...

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Detalhes bibliográficos
Main Authors: Ding, Yousong, Rath, Christopher M., Bolduc, Kyle L., Håkansson, Kristina, Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174474/
https://ncbi.nlm.nih.gov/pubmed/21823639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204716f
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