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Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond Forming NRPS Module
Cryptophycins are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new generation of analogs with improved medicinal properties. Herein, we...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174474/ https://ncbi.nlm.nih.gov/pubmed/21823639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204716f |
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