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Analysis of the Cryptophycin P450 Epoxidase Reveals Substrate Tolerance and Cooperativity
Cryptophycins are potent anticancer agents isolated from Nostoc sp. ATCC 53789 and Nostoc sp. GSV 224. The most potent natural cryptophycin analogues retain a β-epoxide at the C2′-C3′ position of the molecule. A P450 epoxidase encoded by crpE recently identified from the cryptophycin gene cluster wa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697446/ https://ncbi.nlm.nih.gov/pubmed/18366166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710520q |
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