Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

Phenotypic heterogeneity exists within collectively invading packs of tumor cells, suggesting that cellular subtypes cooperate to drive invasion and metastasis. Here, we take a chemical biology approach to probe cell:cell cooperation within the collective invasion pack. These data reveal metabolic h...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Commander, R., Wei, C., Sharma, A., Mouw, J. K., Burton, L. J., Summerbell, E., Mahboubi, D., Peterson, R. J., Konen, J., Zhou, W., Du, Y., Fu, H., Shanmugam, M., Marcus, A. I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093428/
https://ncbi.nlm.nih.gov/pubmed/32210228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15219-7
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