Overcoming fungal echinocandin-resistance through inhibition of the non-essential stress kinase Yck2

New strategies are urgently needed to counter the threat to human health posed by drug-resistant fungi. To explore an as yet unexploited target space for antifungals, we screened a library of protein kinase inhibitors for the ability to reverse resistance of the most common human fungal pathogen, Ca...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Caplan, Tavia, Lorente-Macías, Álvaro, Stogios, Peter J., Evdokimova, Elena, Hyde, Sabrina, Wellington, Melanie A., Liston, Sean, Iyer, Kali R., Puumala, Emily, Shekhar-Guturja, Tanvi, Robbins, Nicole, Savchenko, Alexei, Krysan, Damian J., Whitesell, Luke, Zuercher, William J., Cowen, Leah E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093242/
https://ncbi.nlm.nih.gov/pubmed/31924499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.12.008
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