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Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen’s human host, preventing the use of known clinical...

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Bibliographische Detailangaben
Veröffentlicht in:J Med Chem
Hauptverfasser: Huang, David S., LeBlanc, Emmanuelle V., Shekhar-Guturja, Tanvi, Robbins, Nicole, Krysan, Damian J., Pizarro, Juan, Whitesell, Luke, Cowen, Leah E., Brown, Lauren E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069776/
https://ncbi.nlm.nih.gov/pubmed/31513387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00826
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