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Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen’s human host, preventing the use of known clinical...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Huang, David S., LeBlanc, Emmanuelle V., Shekhar-Guturja, Tanvi, Robbins, Nicole, Krysan, Damian J., Pizarro, Juan, Whitesell, Luke, Cowen, Leah E., Brown, Lauren E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069776/
https://ncbi.nlm.nih.gov/pubmed/31513387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00826
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