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Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors
The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen’s human host, preventing the use of known clinical...
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| Veröffentlicht in: | J Med Chem |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069776/ https://ncbi.nlm.nih.gov/pubmed/31513387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00826 |
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