Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells

BACKGROUND: The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrapancreatic zymogen activation and acute pancreatitis. Stimulation of vacuolar AT...

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Pubblicato in:Genes Nutr
Autori principali: Park, Yeeun, Ku, Leeyeon, Lim, Joo Weon, Kim, Hyeyoung
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092610/
https://ncbi.nlm.nih.gov/pubmed/32293245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12263-020-00664-2
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