Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells

BACKGROUND: The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrapancreatic zymogen activation and acute pancreatitis. Stimulation of vacuolar AT...

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Publicado en:Genes Nutr
Autores principales: Park, Yeeun, Ku, Leeyeon, Lim, Joo Weon, Kim, Hyeyoung
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092610/
https://ncbi.nlm.nih.gov/pubmed/32293245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12263-020-00664-2
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