Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells

BACKGROUND: The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrapancreatic zymogen activation and acute pancreatitis. Stimulation of vacuolar AT...

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Publicat a:Genes Nutr
Autors principals: Park, Yeeun, Ku, Leeyeon, Lim, Joo Weon, Kim, Hyeyoung
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092610/
https://ncbi.nlm.nih.gov/pubmed/32293245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12263-020-00664-2
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