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RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

BACKGROUND: Invasive urothelial carcinoma (iUC) is highly similar between dogs and humans in terms of pathologic presentation, molecular subtypes, response to treatment and age at onset. Thus, the dog is an established and relevant model for testing and development of targeted drugs benefiting both...

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Publicado en:BMC Cancer
Autores principales: Parker, Heidi G., Dhawan, Deepika, Harris, Alex C., Ramos-Vara, Jose A., Davis, Brian W., Knapp, Deborah W., Ostrander, Elaine A.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092566/
https://ncbi.nlm.nih.gov/pubmed/32209086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-06737-0
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