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Conformational States Control Lck Switching between Free and Confined Diffusion Modes in T Cells

T cell receptor phosphorylation by Lck is an essential step in T cell activation. It is known that the conformational states of Lck control enzymatic activity; however, the underlying principles of how Lck finds its substrate over the plasma membrane remain elusive. Here, single-particle tracking is...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biophys J
Päätekijät: Hilzenrat, Geva, Pandžić, Elvis, Yang, Zhengmin, Nieves, Daniel J., Goyette, Jesse, Rossy, Jérémie, Ma, Yuanqing, Gaus, Katharina
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091564/
https://ncbi.nlm.nih.gov/pubmed/32097620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.01.041
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