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How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism
T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor’s immunoreceptor tyrosine-based activation motif domains by the kinase Lck. However, the canonical receptor model is insufficient to explain how the constitutiv...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Research Foundation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377954/ https://ncbi.nlm.nih.gov/pubmed/22723799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00167 |
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