Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity, and protein–protein interactions all contribute to determine how efficiently...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kapoor-Kaushik, Natasha, Hinde, Elizabeth, Compeer, Ewoud B., Yamamoto, Yui, Kraus, Felix, Yang, Zhengmin, Lou, Jieqiong, Pageon, Sophie V., Tabarin, Thibault, Gaus, Katharina, Rossy, Jérémie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782156/
https://ncbi.nlm.nih.gov/pubmed/27014263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00083
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