Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity, and protein–protein interactions all contribute to determine how efficiently...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Kapoor-Kaushik, Natasha, Hinde, Elizabeth, Compeer, Ewoud B., Yamamoto, Yui, Kraus, Felix, Yang, Zhengmin, Lou, Jieqiong, Pageon, Sophie V., Tabarin, Thibault, Gaus, Katharina, Rossy, Jérémie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2016
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782156/
https://ncbi.nlm.nih.gov/pubmed/27014263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00083
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