An intermolecular FRET sensor detects the dynamics of T cell receptor clustering

Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. Here we establish a Förster resonance energy transfer (FRET) sensor, named CliF, which reports intermolecu...

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Udgivet i:Nat Commun
Main Authors: Ma, Yuanqing, Pandzic, Elvis, Nicovich, Philip R., Yamamoto, Yui, Kwiatek, Joanna, Pageon, Sophie V., Benda, Aleš, Rossy, Jérémie, Gaus, Katharina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414349/
https://ncbi.nlm.nih.gov/pubmed/28452360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15100
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