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Hinge-linker elements in the AAA+ protein unfoldase ClpX mediate intersubunit communication, assembly, and mechanical activity
The ClpXP protease plays important roles in protein homeostasis and quality control. ClpX is a ring-shaped AAA+ homohexamer that unfolds target proteins and translocates them into the ClpP peptidase for degradation. AAA+ modules in each ClpX subunit — consisting of a large AAA+ domain, a short hinge...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7091491/ https://ncbi.nlm.nih.gov/pubmed/30418765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00907 |
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