APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticul...

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Publicat a:Cell Rep
Autors principals: Uzureau, Sophie, Lecordier, Laurence, Uzureau, Pierrick, Hennig, Dorle, Graversen, Jonas H., Homblé, Fabrice, Mfutu, Pepe Ekulu, Oliveira Arcolino, Fanny, Ramos, Ana Raquel, La Rovere, Rita M., Luyten, Tomas, Vermeersch, Marjorie, Tebabi, Patricia, Dieu, Marc, Cuypers, Bart, Deborggraeve, Stijn, Rabant, Marion, Legendre, Christophe, Moestrup, Søren K., Levtchenko, Elena, Bultynck, Geert, Erneux, Christophe, Pérez-Morga, David, Pays, Etienne
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090385/
https://ncbi.nlm.nih.gov/pubmed/32187552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.064
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