APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticul...

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Publicado en:Cell Rep
Main Authors: Uzureau, Sophie, Lecordier, Laurence, Uzureau, Pierrick, Hennig, Dorle, Graversen, Jonas H., Homblé, Fabrice, Mfutu, Pepe Ekulu, Oliveira Arcolino, Fanny, Ramos, Ana Raquel, La Rovere, Rita M., Luyten, Tomas, Vermeersch, Marjorie, Tebabi, Patricia, Dieu, Marc, Cuypers, Bart, Deborggraeve, Stijn, Rabant, Marion, Legendre, Christophe, Moestrup, Søren K., Levtchenko, Elena, Bultynck, Geert, Erneux, Christophe, Pérez-Morga, David, Pays, Etienne
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090385/
https://ncbi.nlm.nih.gov/pubmed/32187552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.064
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