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Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome

BACKGROUND: Pancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lu...

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Detalhes bibliográficos
Publicado no:Lung
Main Authors: Gandhi, Chintan K., Holmes, Romel, Gewolb, Ira H., Uhal, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088148/
https://ncbi.nlm.nih.gov/pubmed/30759273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00408-019-00201-y
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