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Innate Inflammation Drives NK Cell Activation to Impair Treg Activity

IL-12 and IL-18 synergize to promote T(H)1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We investigated the influence of these cytokines on immune cells involved in human T1D progression: natural killer (NK) cells, regulatory T cells (Tregs)...

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Bibliographische Detailangaben
Veröffentlicht in:J Autoimmun
Hauptverfasser: Dean, Joseph W., Peters, Leeana D., Fuhrman, Christopher A., Seay, Howard R., Posgai, Amanda L., Stimpson, Scott E., Brusko, Maigan A., Perry, Daniel J., Yeh, Wen-I, Newby, Brittney N., Haller, Michael J., Muir, Andrew B., Atkinson, Mark A., Mathews, Clayton E., Brusko, Todd M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086400/
https://ncbi.nlm.nih.gov/pubmed/32035746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2020.102417
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