Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy

Umbilical cord blood is a traditional and convenient source of cells for hematopoietic stem cell transplantation. Thymic regulatory T cells (Tregs) are also present in cord blood, and there is growing interest in the use of autologous Tregs to provide a low-risk, fully human leukocyte antigen (HLA)-...

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Main Authors: Howard R. Seay, Amy L. Putnam, Judit Cserny, Amanda L. Posgai, Emma H. Rosenau, John R. Wingard, Kate F. Girard, Morey Kraus, Angela P. Lares, Heather L. Brown, Katherine S. Brown, Kristi T. Balavage, Leeana D. Peters, Ashley N. Bushdorf, Mark A. Atkinson, Jeffrey A. Bluestone, Michael J. Haller, Todd M. Brusko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-03-01
Colecção:Molecular Therapy: Methods & Clinical Development
Assuntos:
autoimmunity
cord blood
adoptive cell transfer
regulatory T cell
type 1 diabetes
T cell receptor
good manufacturing practices
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S232905011630136X
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