Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation

BACKGROUND: Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation. For clinical trials, it is essential to have a clinical grade Treg isolation protocol in accordance with Good Manufacturing Practice (GMP) guidelines. To obtain sufficient Treg for...

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Main Authors: Peters, Jorieke H., Preijers, Frank W., Woestenenk, Rob, Hilbrands, Luuk B., Koenen, Hans J. P. M., Joosten, Irma
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522271/
https://ncbi.nlm.nih.gov/pubmed/18776930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003161
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