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Blockade of the mTOR signaling pathway with rapamycin ameliorates aristolochic acid nephropathy

Chronic aristolochic acid nephropathy (CAAN) is characterized by widespread apoptosis and interstitial fibrosis, which severely impairs kidney function. mTOR is crucial for cell proliferation and protein synthesis. In the present study, the therapeutic effects of blockade of mTOR activity by rapamyc...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Wu, Minmin, Tang, Lili, Chen, Bicheng, Zheng, Jianjian, Dong, Fengquan, Su, Zhen, Lin, Fan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086201/
https://ncbi.nlm.nih.gov/pubmed/32256773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.8550
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