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Tuning of pK(a) values activates substrates in flavin-dependent aromatic hydroxylases
Hydroxylation of substituted phenols by flavin-dependent monooxygenases is the first step of their biotransformation in various microorganisms. The reaction is thought to proceed via electrophilic aromatic substitution, catalyzed by enzymatic deprotonation of substrate, in single-component hydroxyla...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7086025/ https://ncbi.nlm.nih.gov/pubmed/32014994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011884 |
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