Tuning of pK(a) values activates substrates in flavin-dependent aromatic hydroxylases

Hydroxylation of substituted phenols by flavin-dependent monooxygenases is the first step of their biotransformation in various microorganisms. The reaction is thought to proceed via electrophilic aromatic substitution, catalyzed by enzymatic deprotonation of substrate, in single-component hydroxyla...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Pitsawong, Warintra, Chenprakhon, Pirom, Dhammaraj, Taweesak, Medhanavyn, Dheeradhach, Sucharitakul, Jeerus, Tongsook, Chanakan, van Berkel, Willem J. H., Chaiyen, Pimchai, Miller, Anne-Frances
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086025/
https://ncbi.nlm.nih.gov/pubmed/32014994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011884
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