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Interactions with the Substrate Phenolic Group Are Essential for Hydroxylation by the Oxygenase Component of p-Hydroxyphenylacetate 3-Hydroxylase

p-Hydroxyphenylacetate (HPA) 3-hydroxylase is a two-component flavoprotein monooxygenase that catalyzes the hydroxylation of p-hydroxyphenylacetate to form 3,4-dihydroxyphenylacetate. Based on structures of the oxygenase component (C(2)), both His-120 and Ser-146 are located ∼2.8 Å from the hydroxyl...

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Bibliografski detalji
Glavni autori: Tongsook, Chanakan, Sucharitakul, Jeerus, Thotsaporn, Kittisak, Chaiyen, Pimchai
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248019/
https://ncbi.nlm.nih.gov/pubmed/22052902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284463
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