An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR

The 300-kDa ClpP1P2 protease from Mycobacterium tuberculosis collaborates with the AAA+ (ATPases associated with a variety of cellular activities) unfoldases, ClpC1 and ClpX, to degrade substrate proteins. Unlike in other bacteria, all of the components of the Clp system are essential for growth and...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Vahidi, Siavash, Ripstein, Zev A., Juravsky, Jordan B., Rennella, Enrico, Goldberg, Alfred L., Mittermaier, Anthony K., Rubinstein, John L., Kay, Lewis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084164/
https://ncbi.nlm.nih.gov/pubmed/32123115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921630117
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