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Reversible inhibition of the ClpP protease via an N-terminal conformational switch

Protein homeostasis is critically important for cell viability. Key to this process is the refolding of misfolded or aggregated proteins by molecular chaperones or, alternatively, their degradation by proteases. In most prokaryotes and in chloroplasts and mitochondria, protein degradation is perform...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Vahidi, Siavash, Ripstein, Zev A., Bonomi, Massimiliano, Yuwen, Tairan, Mabanglo, Mark F., Juravsky, Jordan B., Rizzolo, Kamran, Velyvis, Algirdas, Houry, Walid A., Vendruscolo, Michele, Rubinstein, John L., Kay, Lewis E.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048506/
https://ncbi.nlm.nih.gov/pubmed/29941580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805125115
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