Preclinical efficacy of the first-in-class GPER-selective agonist G-1 in mouse models of obesity and diabetes

Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in women following menopause greatly increases the risk of obesity and metabolic dysfunction, revealing the critical role of E2 in...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Sharma, Geetanjali, Hu, Chelin, Staquicini, Daniela I., Brigman, Jonathan L., Liu, Meilian, Mauvais-Jarvis, Franck, Pasqualini, Renata, Arap, Wadih, Arterburn, Jeffrey B., Hathaway, Helen J., Prossnitz, Eric R.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083206/
https://ncbi.nlm.nih.gov/pubmed/31996464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau5956
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