Preclinical efficacy of the first-in-class GPER-selective agonist G-1 in mouse models of obesity and diabetes

Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in women following menopause greatly increases the risk of obesity and metabolic dysfunction, revealing the critical role of E2 in...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Sharma, Geetanjali, Hu, Chelin, Staquicini, Daniela I., Brigman, Jonathan L., Liu, Meilian, Mauvais-Jarvis, Franck, Pasqualini, Renata, Arap, Wadih, Arterburn, Jeffrey B., Hathaway, Helen J., Prossnitz, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083206/
https://ncbi.nlm.nih.gov/pubmed/31996464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau5956
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