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MiRNA Targeting – Growing Beyond the Seed

MicroRNAs (miRNAs) are small RNAs that guide Argonaute (AGO) proteins to specific target messenger RNAs (mRNAs) to repress their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the seed region, nucleotides (nts) 2–7, of the miRNA to sites in mRNA 3’UTRs. Recentl...

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Detalles Bibliográficos
Publicado en:Trends Genet
Main Authors: Chipman, Laura B., Pasquinelli, Amy E.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083087/
https://ncbi.nlm.nih.gov/pubmed/30638669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2018.12.005
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