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About miRNAs, miRNA seeds, target genes and target pathways

miRNAs are typically repressing gene expression by binding to the 3’ UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kehl, Tim, Backes, Christina, Kern, Fabian, Fehlmann, Tobias, Ludwig, Nicole, Meese, Eckart, Lenhof, Hans-Peter, Keller, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739805/
https://ncbi.nlm.nih.gov/pubmed/29291020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22363
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