In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

BACKGROUND AND PURPOSE: Tuberculosis has been reported to be the worldwide leading cause of death resulting from a sole infectious agent. The emergence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis has made the battle against the infection more difficult since most...

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Publicado en:Drug Des Devel Ther
Autores principales: Venugopala, Katharigatta N, Tratrat, Christophe, Pillay, Melendhran, Chandrashekharappa, Sandeep, Al-Attraqchi, Omar Husham Ahmed, Aldhubiab, Bandar E, Attimarad, Mahesh, Alwassil, Osama I, Nair, Anroop B, Sreeharsha, Nagaraja, Venugopala, Rashmi, Morsy, Mohamed A, Haroun, Michelyne, Kumalo, Hezekiel M, Odhav, Bharti, Mlisana, Koleka
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082623/
https://ncbi.nlm.nih.gov/pubmed/32214795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S228381
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