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In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

BACKGROUND AND PURPOSE: Tuberculosis has been reported to be the worldwide leading cause of death resulting from a sole infectious agent. The emergence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis has made the battle against the infection more difficult since most...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Venugopala, Katharigatta N, Tratrat, Christophe, Pillay, Melendhran, Chandrashekharappa, Sandeep, Al-Attraqchi, Omar Husham Ahmed, Aldhubiab, Bandar E, Attimarad, Mahesh, Alwassil, Osama I, Nair, Anroop B, Sreeharsha, Nagaraja, Venugopala, Rashmi, Morsy, Mohamed A, Haroun, Michelyne, Kumalo, Hezekiel M, Odhav, Bharti, Mlisana, Koleka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082623/
https://ncbi.nlm.nih.gov/pubmed/32214795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S228381
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