Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef

The HIV-1 accessory protein Nef downregulates the cell surface expression of major histocompatibility complex class I (MHC-I) molecules to facilitate virus spreading. The Nef-induced downregulation of MHC-I molecules such as HLA-A requires the clathrin adaptor protein 1 (AP-1) complex. The cooperati...

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Publicat a:J Virol
Autors principals: Tavares, Lucas A., de Carvalho, Julianne V., Costa, Cristina S., Silveira, Roberta M., de Carvalho, Andreia N., Donadi, Eduardo A., daSilva, Luis L. P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081889/
https://ncbi.nlm.nih.gov/pubmed/31915283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02039-19
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