Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

BACKGROUND: Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific re...

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Détails bibliographiques
Publié dans:Clin Epigenetics
Auteurs principaux: Lawrence, Mitchell G., Pidsley, Ruth, Niranjan, Birunthi, Papargiris, Melissa, Pereira, Brooke A., Richards, Michelle, Teng, Linda, Norden, Sam, Ryan, Andrew, Frydenberg, Mark, Stirzaker, Clare, Taylor, Renea A., Risbridger, Gail P., Clark, Susan J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081708/
https://ncbi.nlm.nih.gov/pubmed/32188493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00836-2
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