Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

BACKGROUND: Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific re...

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Dades bibliogràfiques
Publicat a:Clin Epigenetics
Autors principals: Lawrence, Mitchell G., Pidsley, Ruth, Niranjan, Birunthi, Papargiris, Melissa, Pereira, Brooke A., Richards, Michelle, Teng, Linda, Norden, Sam, Ryan, Andrew, Frydenberg, Mark, Stirzaker, Clare, Taylor, Renea A., Risbridger, Gail P., Clark, Susan J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081708/
https://ncbi.nlm.nih.gov/pubmed/32188493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00836-2
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