Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

T cells play a critical role in controlling viral infection; however, the mechanisms regulating their responses remain incompletely understood. Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Dang, Xindi, Ogbu, Stella C., Zhao, Juan, Nguyen, Lam Ngoc Thao, Cao, Dechao, Nguyen, Lam Nhat, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Wu, Xiao Y., Morrison, Zheng D., Zhang, Jinyu, Li, Zhengke, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Wang, Zhengqiang, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081277/
https://ncbi.nlm.nih.gov/pubmed/32193368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2395-2
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