Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

T cells in chronic viral infections are featured by premature aging with accelerated telomere erosion, but the mechanisms underlying telomere attrition remain unclear. Here, we employed human CD4 T cells treated with KML001 (a telomere-targeting drug) as a model to investigate the role of telomere i...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cao, Dechao, Zhao, Juan, Nguyan, Lam N., Nguyen, Lam N. T., Khanal, Sushant, Dang, Xindi, Schank, Madison, Chand Thakuri, Bal K., Wu, Xiao Y., Morrison, Zheng D., El Gazzar, Mohamed, Zou, Yue, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540964/
https://ncbi.nlm.nih.gov/pubmed/31191531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01152
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