ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined antiretroviral therapy (cART) with undetectable viremia. In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machiner...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhao, Juan, Nguyen, Lam Ngoc Thao, Nguyen, Lam Nhat, Dang, Xindi, Cao, Dechao, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Ogbu, Stella C., Morrison, Zheng D., Wu, Xiao Y., Li, Zhengke, Zou, Yue, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856652/
https://ncbi.nlm.nih.gov/pubmed/31781094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02531
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