Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer

This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mous...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Nikhil, Kumar, Chang, Lei, Viccaro, Keith, Jacobsen, Max, McGuire, Callista, Satapathy, Shakti R., Tandiary, Michael, Broman, Meaghan M., Cresswell, Gregory, He, Yizhou J., Sandusky, George E., Ratliff, Timothy L., Chowdhury, Dipanjan, Shah, Kavita
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079209/
https://ncbi.nlm.nih.gov/pubmed/30716360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.01.035
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