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The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT-specific target of AURKA that was identified using an innovative screen. AURKA phosphorylates Twist1 at th...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5358340/ https://ncbi.nlm.nih.gov/pubmed/28167680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196790 |
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