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Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
BACKGROUND: SPOP, an E3 ubiquitin ligase adaptor, can act either as a tumour suppressor or a tumour promoter. In prostate cancer (PCa), it inhibits tumorigenesis by degrading several oncogenic substrates. SPOP is the most altered gene in PCa (~15%), which renders it ineffective, promoting cancer. Th...
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| Vydáno v: | Br J Cancer |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7921662/ https://ncbi.nlm.nih.gov/pubmed/33311589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01197-6 |
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